Discovery of the neutralizing epitope common to influenza B virus victoria group isolates in Japan.
نویسندگان
چکیده
Monoclonal antibody 9B2 possesses hemagglutination inhibition activity against all the 2002/2003 influenza B virus Victoria group isolates in Kobe, Japan, as well as representative strains isolated between 1987 and 1997. The 9B2 epitope localizes three-dimensionally in the vicinity of antigenic site A of the hemagglutinin molecule, and amino acid substitutions in this region affected the binding of 9B2.
منابع مشابه
Variation of the conserved neutralizing epitope in influenza B virus victoria group isolates in Japan.
For almost 20 years, the neutralizing-epitope site specific for influenza B virus Victoria group isolates was conserved at the "tip" of the hemagglutinin molecule; however, it was not detected in half of the isolates from the 2002-2003 epidemic in Japan. Amino acid substitutions (D164E or N165K) were observed at the "tip", and the epitope was altered. The viral antigenicities were affected, and...
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ورودعنوان ژورنال:
- Journal of clinical microbiology
دوره 44 4 شماره
صفحات -
تاریخ انتشار 2006